The Republicans have a confirmed seven seat pick up to give them 52 seats and are well placed to get Alaska and Louisiana also. If they do it will be the best mid-term gain for the Republicans since 1958.
In Alaska the Republican candidate is 8,000 votes ahead with 50,000 to be counted.
There is a run off in Louisiana but they have a system where there are no primaries so there were multiple Republican candidates. The Democratic candidate got 42%, and the next two candidates were Republicans on 41% and 14% so I expect a win there also.
In the House the Republicans so far have a net gain of 12 seats with seven undecided. They have a chance of a pick up in five of those seats and if they get just one of them, it will be their largest majority if the House since 1928. That gives you an idea of how huge a victory this turned out to be.